InterPro domain: IPR022003

The RST (for RCD1 SRO TAF4) domain is a plant-specific domain found in WWE- PARPs (poly(ADP-ribose) polymerase) and TAF4s (TBP-Associated Factor 4), a component of several multimeric protein complexes including primarily the general transcription factor TFIID involved in transcriptional initiation. The RST domain is a protein-protein interaction domain suggested to be critical for the interaction with several, mostly plant-specific transcription factors [ 1 , 2 ].

The RST domain structure has a unique helical arrangement composed of four alpha helices flanked by disordered termini. The four-helix fold of the RST domain organizes in an open, hydrophobic L-shape with room for catching the ligand [ 3 ]. A strong conservation of a large number of aliphatic amino acids in the N- and C-termini of the RST domain, with a conserved tyrosine in the middle of the domain and two conserved positively charged amino acids in the second half of the domain, is striking [ 4 ]. This entry represents the RST domain.

1. The RST and PARP-like domain containing SRO protein family: analysis of protein structure, function and conservation in land plants. BMC Genomics 26, 734-746.e7
2. Unequally redundant RCD1 and SRO1 mediate stress and developmental responses and interact with transcription factors. Plant J. 11, 170
3. Structure of Radical-Induced Cell Death1 Hub Domain Reveals a Common ??-Scaffold for Disorder in Transcriptional Networks. Structure