InterPro domain: IPR021935
General Information
- Identifier IPR021935
- Description Small G protein signalling modulator 1/2, Rab-binding domain
- Number of genes 152
- Gene duplication stats Loading...
Abstract
This domain adopts a PH-like fold. It has been called the Rab-binding domain (RBD) [ 1 ].
Small G-protein signalling modulator 1/2 (also known as RUTBC2/1) bind to Rab9A via their Pleckstrin homology (PH) domain [ 2 , 3 ]. RUTBC1 stimulates GTP hydrolysis by Rab32 and Rab33B [ 4 ], while RUTBC2 appears to be a GAP for Rab36, Rab9A and associated proteins controling the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi [ 4 , 4 , 4 ].
1. Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Structure 22, 1408-20
2. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. J. Biol. Chem. 287, 22740-8
3. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J. Biol. Chem. 291, 1427-40
4. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Genomics 90, 249-60