InterPro domain: IPR021906

This entry represents the mammalian BAF250a/b and its homologue osa from fruit flies [ 1 ]. They are part of the SWI/SNF-like ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling. In humans there are two BAF250 isoforms, BAF250a/ARID1a and BAF250b/ARID1b. BAF250a/b may be E3 ubiquitin ligases that target histone H2B [ 2 ].

This entry also includes Arabidopsis LFR protein, which is involved in leaf and flower development [ 3 ] and is required for the formation of anther cell layers and normal expression of genes that regulates anther development [ 4 ].

1. Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes. Genes Dev. 14, 3140-52
2. Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. Mol. Cell. Biol. 30, 1673-88
3. LFR, which encodes a novel nuclear-localized Armadillo-repeat protein, affects multiple developmental processes in the aerial organs in Arabidopsis. Plant Mol. Biol. 69, 121-31
4. The Arabidopsis LFR gene is required for the formation of anther cell layers and normal expression of key regulatory genes. Mol Plant 5, 993-1000