InterPro domain: IPR021886
General Information
- Identifier IPR021886
- Description MgsA AAA+ ATPase C-terminal
- Number of genes 109
- Gene duplication stats Loading...
Abstract
The MgsA protein possesses DNA-dependent ATPase and ssDNA annealing activities [ 1 ]. MgsA contributes to the recovery of stalled replication forks and therefore prevents genomic instability caused by aberrant DNA replication [ 2 ]. Additionally, MgsA may play a role in chromosomal segregation [ 2 ]. This is consistent with a report that MgsA co-localises with the replisome and affects chromosome segregation [ 2 ]. This domain represents the C-terminal region of MgsA. The structure of MgsA has been solved [ 2 ].
1. Functional overlap between RecA and MgsA (RarA) in the rescue of stalled replication forks in Escherichia coli. Genes Cells 10, 181-91
2. Structure and biochemical activities of Escherichia coli MgsA. J. Biol. Chem. 286, 12075-85