InterPro domain: IPR021771

This is an N-terminal domain that is found adjacent to the patatin/phospholipase A2-related domain (see IPR002641 ) in a group of proteins. Proteins containing this domain include Tgl3/4/5 from Saccharomyces cerevisiae. Tgl3 is a bifunctional triacylglycerol lipase and lysophospholipid acyltransferase [ 1 ]. Tgl4/5 are multifunctional lipase/hydrolase/phospholipases [ 2 , 3 ]. They are generally involved in triacylglycerol mobilisation and localized to lipid particles [ 4 , 4 ].

This entry also includes plant sugar-dependent 1 (SDP1) protein, which is a triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds [ 5 , 6 ].

1. YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. J. Biol. Chem. 278, 23317-23
2. Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. J. Biol. Chem. 280, 37301-9
3. Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae. J. Biol. Chem. 285, 15769-76
4. Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions. Mol. Biol. Cell 21, 501-10
5. SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds. Plant Cell 18, 665-75
6. Storage oil hydrolysis during early seedling growth. Plant Physiol. Biochem. 47, 485-90