InterPro domain: IPR021622

This family is found in mammals where it is localised at cell-cell adherens junctions [ 1 ], and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules [ 2 ]. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.

1. ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. J. Biol. Chem. 278, 4103-11
2. Gamma-tubulin complex-mediated anchoring of spindle microtubules to spindle-pole bodies requires Msd1 in fission yeast. Nat. Cell Biol. 9, 646-53