InterPro domain: IPR021538

General Information

  • Identifier IPR021538
  • Description Syntaxin-5, N-terminal, Sly1p-binding domain
  • Number of genes 195
  • Gene duplication stats Loading...

Abstract

This entry represents the Sed5 N-terminal and the N terminus of Syntaxin-5-like proteins. It is the region of Syntaxin that interacts with Sly1p, a positive regulator of intracellular membrane fusion, allowing SM (cytosolic Sec1/munc18-like) proteins to stay associated with the assembling fusion machinery. This allows the SM proteins to participate in late fusion steps [ 1 ].


1. Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p. EMBO J. 21, 6114-24

Species distribution

Gene table