InterPro domain: IPR021182

This entry represents proteins SOSEKI 1-5 (SOK1-5) from Arabidopsis thaliana. SOSEKI proteins (SOK1-5) integrate apical-basal and radial organismal axes to localize to polar cell edges and contain a DIX oligomerization domain that resembles that in the animal Dishevelled polarity regulator [ 1 , 2 ]. SOK2 is also known as Protein UPSTREAM OF FLC (UFC, At5g10150) and is part of a three-gene cluster containing FLC, UFC and DFC, which is coordinately regulated in response to vernalization [ 3 , 4 ].

1. A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis. Nat Plants 5, 160-166
2. DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes. Cell 180, 427-439.e12
3. A cluster of Arabidopsis genes with a coordinate response to an environmental stimulus. Curr. Biol. 14, 911-6
4. The FLX gene of Arabidopsis is required for FRI-dependent activation of FLC expression. Plant Cell Physiol 49, 191-200