InterPro domain: IPR021148

This domain can be found in IRX15/IRX15L/IGXM from plants and in protein PBDC1 from animals and fungi.

IRX15/IRX15L and IGXM play a role in xylan biosynthesis in plant cell walls. However, they have different functions [ 1 ]. The function of IRX15/IRX15L is not clear. GXM1/GXM2/GXM3 are methyltransferases catalysing 4-O-methylation of GlcA side chains on xylan [ 2 , 3 ].

The function of PBDC1 (polysaccharide biosynthesis domain-containing protein) is not clear.

1. Modification of the degree of 4-O-methylation of secondary wall glucuronoxylan. Plant Sci. 219-220, 42-50
2. Three Arabidopsis DUF579 domain-containing GXM proteins are methyltransferases catalyzing 4-o-methylation of glucuronic acid on xylan. Plant Cell Physiol. 53, 1934-49