InterPro domain: IPR021102

General Information

  • Identifier IPR021102
  • Description Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A
  • Number of genes 383
  • Gene duplication stats Loading...

Abstract

Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A (PNGase A), unlike many other amidases, is capable of hydrolysing glycopeptides with an alpha-1,3-fucosylated asparagine-bound N-acetylglucosamine (GlcNAc). PNGase A is a heterodimer composed of a large and small subunit [ 1 ]. This entry represents the PNGase A precursor, which contains both subunits and is activated by proteolytic cleavage.


1. Characterisation of peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A and its N-glycans. Eur. J. Biochem. 252, 118-23

Species distribution

Gene table