InterPro domain: IPR020779
General Information
- Identifier IPR020779
- Description dNTP triphosphohydrolase, type 1
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0000287 GO:0008832 GO:0006203
Abstract
This entry represents a subgroup of dNTP triphosphohydrolases mostly from gamma-proteobacteria. Proteins in this entry include dGTPase from E. coli and PA1124 ( Q9I4L1 ) from Pseudomonas aeruginosa. They are triphosphohydrolases that have a preference for dGTP [ 1 ].
Interestingly, E. coli dGTPase (Dgt) has been shown to have a strong single-stranded DNA-binding (ssDNA) activity [ 2 ].
1. Two dNTP triphosphohydrolases from Pseudomonas aeruginosa possess diverse substrate specificities. FEBS J. 276, 3211-21
2. Structure of Escherichia coli dGTP triphosphohydrolase: a hexameric enzyme with DNA effector molecules. J. Biol. Chem. 290, 10418-29
Species distribution
Gene table
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