InterPro domain: IPR020532

This entry represents the enzyme cycloeucalenol cycloisomerase ( 5.5.1.9 ) and is involved in the synthesis of plant sterols, by converting pentacyclic cyclopropyl sterols to tetracyclic sterols [ 1 ].

In Arabidopsis thaliana (Mouse-ear cress), cycloeucalenol cycloisomerase functions during and just after division and supports gravitropism by establishing polar PIN2 (auxin transporter) localisation, it is also required for endocytosis of PIN2 [ 2 ].

1. Functional cloning of an Arabidopsis thaliana cDNA encoding cycloeucalenol cycloisomerase. J. Biol. Chem. 275, 13394-7
2. Sterol-dependent endocytosis mediates post-cytokinetic acquisition of PIN2 auxin efflux carrier polarity. Nat. Cell Biol. 10, 237-44