InterPro domain: IPR019538

General Information

  • Identifier IPR019538
  • Description 26S proteasome non-ATPase regulatory subunit 5
  • Number of genes 122
  • Gene duplication stats Loading...
  • Associated GO terms GO:0043248  

Abstract

The 26S proteasome is an enzymatic complex that degrades ubiquitinated proteins in eukaryotic cells. 26S proteasome non-ATPase regulatory subunit 5 (PSMD5) is one of a number of chaperones that are involved in the assembly of the proteasome. The chaperones dissociate before 26S proteasome formation is complete [ 1 ].

TNF-alpha/NFkB inhibits 26S proteasome assembly via abnormal expressionof PSMD5, establishing a link between inflammation and chronic neurodegenerativediseases with altered ubiquitin-proteasome system function [ 2 ].


1. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Cell 137, 914-25
2. Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes. Cell Rep 2, 603-15

Species distribution

Gene table