InterPro domain: IPR019519

Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The human Elongator six-subunit complex, known as holo-Elongator, has histone acetyltransferase activity directed against histone H3 and H4 [ 1 , 2 ]. It consists of two subcomplexes, a core subcomplex (ELP1-3), and an accessory subcomplex (ELP4-6) [ 3 ]. The elongator complex has been associated with many cellular activities, including transcriptional elongation [ 4 , 5 ], but its main function is tRNA modification [ 6 , 7 ]. It is required for the formation of 5-methoxy-carbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups on uridine nucleosides present at the wobble position of many tRNAs [ 8 ].

This entry represents Elongator complex protein 5 (ELP5).

1. Purification and characterization of the human elongator complex. J. Biol. Chem. 277, 3047-52
2. Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc. Natl. Acad. Sci. U.S.A. 99, 3517-22
3. Crystal structure of elongator subcomplex Elp4-6. J. Biol. Chem. 287, 21501-8
4. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol. Cell 3, 109-18
5. Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 21, 8203-12
6. An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 11, 424-36
7. A coordinated codon-dependent regulation of translation by Elongator. Cell Cycle 11, 4524-9
8. Elongator: transcriptional or translational regulator? Transcription 3, 273-6