InterPro domain: IPR019510
General Information
- Identifier IPR019510
- Description Protein kinase A anchor protein, nuclear localisation signal domain
- Number of genes 151
- Gene duplication stats Loading...
Abstract
This entry represents the nuclear localisation signal-containing domain found in the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes [ 1 ]. This domain carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein [ 2 ].
The domain is also found in a number of other proteins, such as activating signal cointegrator 1 complex subunit 1 and leukocyte receptor cluster member 9.
1. AKAP7gamma is a nuclear RI-binding AKAP. Biochem. Biophys. Res. Commun. 306, 394-401
2. High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem. J. 396, 297-306