InterPro domain: IPR019496

Nuclear fragile X mental retardation-interacting protein 1 (Nufip1) has been implicated in the assembly of the large subunit of the ribosome [ 1 ] and in telomere maintenance [ 2 ]. It is known to bind RNA [ 3 ] and is phosphorylated upon DNA damage [ 4 ]. This entry represents a conserved domain found within Nufip1. Some proteins containing this region also contain a CCCH zinc finger.

1. Synthetic lethality with conditional dbp6 alleles identifies rsa1p, a nucleoplasmic protein involved in the assembly of 60S ribosomal subunits. Mol. Cell. Biol. 19, 8633-45
2. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet. 2, e35
3. A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Hum. Mol. Genet. 8, 2557-66
4. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6