InterPro domain: IPR019458

General Information

  • Identifier IPR019458
  • Description Telomerase activating protein Est1, N-terminal
  • Number of genes 314
  • Gene duplication stats Loading...

Abstract

Est1 is directly involved in telomere replication. It associates with telomerase and, during its interaction with CDC13, telomerase activity is promoted [ 1 , 2 ].


1. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science 297, 1023-6
2. The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. Genetics 162, 1101-15

Species distribution

Gene table