InterPro domain: IPR019389

This entry represents selenoprotein T (SelT), which is conserved from plants to humans. SelT is localized to the endoplasmic reticulum through a hydrophobic domain. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding [ 1 , 2 ]. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. The function of SelT is unknown, although it may have a role in PACAP signaling during PC12 cell differentiation [ 3 , 4 ].

1. Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells. J. Biol. Chem. 276, 15330-6
2. Structure-function relationships, physiological roles and evolution of mammalian ER-resident selenoproteins. Antioxid. Redox Signal. 22, 1756-68
3. Identification of novel genes expressed in hypoxic brain condition by fluorescence differential display. Forensic Sci. Int. 169, 168-72
4. Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion. FASEB J.