InterPro domain: IPR019385
General Information
- Identifier IPR019385
- Description Phosphorylated adapter RNA export protein, RNA-binding domain
- Number of genes 141
- Gene duplication stats Loading...
Abstract
The phosphorylated adaptor for RNA export (PHAX) protein transports U3 snoRNA from the nucleus after transcription [ 1 , 2 ]. This entry represents the highly conserved U3 snoRNA-binding domain of PHAX, which is characterised by having two pairs of adjacent glycines with the sequence motif GGx12GG. This domain adopts a novel helical fold and binds non-specific single-stranded RNA and comprises five alpha-helices linked by short loops containing 1 to 4 residues, apart from helices alpha3 and 4 that are linked by 13 residues. The fold is unique to this kind of RNA binding domains which show no structural homology with other RNA-binding domains [ 3 ].
1. The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export. RNA 7, 351-60
2. Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX. RNA 16, 1205-16