InterPro domain: IPR019354
General Information
- Identifier IPR019354
- Description Smg8/Smg9
- Number of genes 115
- Gene duplication stats Loading...
- Associated GO terms GO:0000184
Abstract
Smg8 and Smg9 are two subunits of the Smg-1 complex. They suppress Smg-1 kinase activity in the isolated Smg-1 complex, and are involved in nonsense-mediated mRNA decay (NMD) in both mammals and nematodes [ 1 ]. NMD is a surveillance mechanism that detects and degrades mRNAs containing premature translation termination codons.
1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 23, 1091-105
Species distribution
Gene table
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