InterPro domain: IPR019352

General Information

  • Identifier IPR019352
  • Description SREBP regulating gene protein
  • Number of genes 115
  • Gene duplication stats Loading...
  • Associated GO terms GO:2000640  

Abstract

SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP [ 1 ].


1. Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. Nat Commun 11, 1128

Species distribution

Gene table