InterPro domain: IPR019340

This entry is found in Ada3 and homologous proteins which function as part of histone acetyltransferase complexes [ 1 ]. Ada3 is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. It plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage [ 2 ].

1. ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2. Mol. Cell. Biol. 13, 5981-9
2. An essential role of human Ada3 in p53 acetylation. J. Biol. Chem. 282, 8812-20