InterPro domain: IPR019337

This entry represents a conserved domain found in a group of proteins called telomere-length regulation TEL2, or clock abnormal protein-2, which are conserved from plants to humans. These proteins regulate telomere length and contribute to silencing of sub-telomeric regions [ 1 ]. Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling [ 2 ]. In vitro the protein binds to telomeric DNA repeats.

1. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 128, 4045-55
2. Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev. 22, 854-9