InterPro domain: IPR019331

This entry represents the N-terminal domain of the mammalian PIP30/FAM192A protein and the fungal Fyv6 protein.

PIP30/FAM192A acts as a regulator of PA28-gamma, a nuclear activator of the 20S proteasome. PIP30 favors PA28-gamma interaction with the 20S proteasome while inhibiting its association with coilin, a central component of nuclear Cajal bodies [ 1 ].

Fyv6 is involved in telomere length regulation and required for survival upon exposure to K1 killer toxin [ 2 , 3 ]. It promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase [ 4 ].

1. PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ. Proc. Natl. Acad. Sci. U.S.A. 115, E6477-E6486
2. A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin. Genetics 163, 875-94
3. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet. 2, e35
4. A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Genetics 162, 677-88