InterPro domain: IPR019328

General Information

  • Identifier IPR019328
  • Description GPI-GlcNAc transferase complex, PIG-H component, conserved domain
  • Number of genes 117
  • Gene duplication stats Loading...
  • Associated GO terms GO:0017176  

Abstract

This entry represents a conserved domain found in PIG-H proteins. PIG-H is a family of conserved proteins that are part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [ 1 , 2 ] and it is involved in the first step in GPI anchor formation.


1. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J. 17, 877-85
2. Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly. Yeast 18, 1383-9

Species distribution

Gene table