InterPro domain: IPR019308

General Information

  • Identifier IPR019308
  • Description Transmembrane protein 214
  • Number of genes 390
  • Gene duplication stats Loading...

Abstract

TMEM214 is a critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. It is required or the activation of CASP4 following endoplasmic reticulum stress [ 1 ].


1. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. J. Biol. Chem. 288, 17908-17

Species distribution

Gene table