InterPro domain: IPR019265

This entry represents RNA transcription, translation and transport factor protein (RTRAF, also known as hCLE/C14orf166) from eukaryotes. It is part of the DDX1-HSPC117-FAM98B complex that shuttles between the nucleus and the cytoplasm transporting RNAs [ 1 ]. It is also a component of the tRNA-splicing ligase complex and is required for tRNA ligation [ 2 ]. Human RTRAF works as a positive modulator of the RNA polymerase II activity [ 3 ]. It also interacts with influenza virus polymerase subunit PA and plays an important role in influenza virus replication [ 4 ].

1. hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. PLoS ONE 9, e90957
2. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. Nature 511, 104-7
3. hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. J. Mol. Biol. 362, 887-900
4. Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. J. Virol. 85, 12062-6