InterPro domain: IPR019185

Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1) [ 1 ]. Sys1p is a small integral membrane protein with four predicted transmembrane domains that localises to the Trans Golgi network TGN in yeast and human cells [ 2 ].

1. Membrane targeting: getting Arl to the Golgi. Curr. Biol. 14, R483-5
2. Arl1p is involved in transport of the GPI-anchored protein Gas1p from the late Golgi to the plasma membrane. J. Cell. Sci. 119, 3845-55