InterPro domain: IPR019181

General Information

  • Identifier IPR019181
  • Description Anticodon-binding domain
  • Number of genes 147
  • Gene duplication stats Loading...

Abstract

This domain of approximately 100 residues is conserved from plants to humans. It is an anticodon-binding domain of a prolyl-tRNA synthetase [ 1 ]. It is found in Lms12 and homologues. Lsm12 isa protein possibly involved in mRNA degradation or tRNA splicing [ 2 ].


1. A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase. J. Mol. Biol. 309, 989-1002
2. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett. 569, 18-26

Species distribution

Gene table