InterPro domain: IPR019167

This entry represents a domain found in Pat1 and its homologues.

Pat1 is involved in translational repression and enhanced mRNA decay. It is part of the Lsm1-7-Pat1 complex that plays a role in activation of deadenylation-dependent decapping in the 5' to 3' pathway and in the protection of mRNA 3' ends [ 1 ].

There are two Pat1 homologues in vertebrates, Pat1a and Pat1b, in contrast to the single protein in yeast and invertebrates. The maternally expressed Pat1a protein acts as a translational repressor, while Pat1b functions in mRNA decay in somatic cells. Pat1b is localised to P-body and is a nucleocytoplasmic shuttling protein that may perform various nuclear functions upstream of their multiple posttranscriptional regulatory roles in the cytoplasm [ 2 ].

1. Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex. RNA 20, 1465-75
2. RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor. Mol. Biol. Cell 23, 213-24