InterPro domain: IPR019159

This entry represents the coiled-coil domain found in CCDC93.

Human CCDC93 is part of the COMMD/CCDC22/CCDC93 (CCC) complex that interacts with the multisubunit WASH complex, which is required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer [ 1 ]. The CCC complex controls Notch activation by modulating its intracellular trafficking [ 2 ].

1. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol. Biol. Cell 26, 91-103
2. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J. Cell Biol. 211, 605-17