InterPro domain: IPR019098

This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones [ 1 ].

1. Chz1, a nuclear chaperone for histone H2AZ. Mol. Cell 25, 357-68