InterPro domain: IPR019050

The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops [ 1 ]. It is found at the C terminus of Scd6p-like SM domains [ 2 , 2 ]. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N-terminal to the YjeF-N domain, a novel Rossmann fold domain [ 3 ].

1. Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. BMC Genomics 5, 45
2. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett. 569, 18-26