InterPro domain: IPR019038

POLD3 is a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. It is required for optimal Pol-delta activity [ 1 , 2 , 3 , 4 , 5 ].

1. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. Nucleic Acids Res. 27, 2108-14
2. Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. Biochemistry 39, 7245-54
3. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. J. Biol. Chem. 276, 49258-66
4. Functional roles of p12, the fourth subunit of human DNA polymerase delta. J. Biol. Chem. 281, 14748-55
5. Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ. DNA Repair (Amst.) 12, 922-35