InterPro domain: IPR019012
General Information
- Identifier IPR019012
- Description RNA cap guanine-N2 methyltransferase
- Number of genes 206
- Gene duplication stats Loading...
- Associated GO terms GO:0001510 GO:0009452 GO:0008168
Abstract
RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe (Fission yeast) trimethylguanosine synthase (Tgs1) and Giardia lamblia (Giardia intestinalis) Tgs2, catalyse the methylation step(s) for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure [ 1 , 2 , 3 ]. Trimethylguanosine synthase is specific for guanine, and N7 methylation must precede N2 methylation. This enzyme is required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. As such, this enzyme plays a role in transcriptional regulation.
1. Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. Nucleic Acids Res. 35, 1411-20
2. Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1. J. Cell. Sci. 121, 3553-60
3. Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). J. Biol. Chem. 280, 4021-4