InterPro domain: IPR019010

This entry represents the N-terminal domain of the eukaryotic translation initiation factor 3 subunit E. EIF3 is required in protein synthesis in mammalian cells and, together with other initiation factors, stimulates binding of initiator methionyl-tRNAi and mRNA to the 40S ribosomal subunit to form the 48 S initiation complex [ 1 ]. The eIF3 complex also prevents premature association of the 40 and 60 S ribosomal subunits and interacts with other initiation factors involved in start codon selection. EIF3 has at least 13 protein components (eIF3a-m or 1-13), where subunits h, i, k, and m are likely to be on the periphery of the complex [ 2 ]. Subunit 6 is produced by the int6 gene, one of the frequent integration sites for mouse mammary tumor viruses [ 2 ].

1. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol. Cell Proteomics 6, 1135-46
2. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. J. Biol. Chem. 283, 22063-75