InterPro domain: IPR018860

The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [ 1 ].

This entry represents subunit CDC26, whose exact function is not known [ 2 ].

1. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133, 653-65
2. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. Proc. Natl. Acad. Sci. U.S.A. 97, 8973-8