InterPro domain: IPR018800

This family constitutes the major, conserved, portion of PRCC proteins. In humans,this family interacts with MAD2B, the mitotic checkpoint protein [ 1 , 2 ]. In Schizosaccharomyces pombe this protein is part of the Cwf-complex that is known to be involved in pre-mRNA splicing [ 3 ].

1. Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. Proc. Natl. Acad. Sci. U.S.A. 93, 15294-8
2. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. Proc. Natl. Acad. Sci. U.S.A. 98, 13808-13
3. Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Mol. Cell. Biol. 22, 2011-24