InterPro domain: IPR018737

General Information

  • Identifier IPR018737
  • Description Protein LIN52
  • Number of genes 59
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006351   GO:0070176  

Abstract

LIN52 is a component of the DREAM (MuvB/DRM) complex which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [ 1 , 2 ].


1. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol. Cell 26, 539-51
2. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Cell Cycle 6, 1903-13

Species distribution

Gene table