InterPro domain: IPR018552

Centromere protein X (CENP-X) is a component of several different complexes, including the multisubunit FA complex, the heterotetrameric CENP-T-W-S-X complex and the APITD1/CENPS complex.

The Fanconi anemia (FA) core complex is involved in DNA damage repair and genome maintenance. The FA complex is composed of CENPS, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and CENPX. Interacts with CENPS, FANCM and FAAP24 [ 1 , 2 ]. Inner kinetochore subunit mhf2 is the dsDNA-binding component of the FANCM-MHF complex, important for gene conversion at blocked replication forks [ 3 ] and non-crossover recombination during mitosis and meiosis [ 3 ].

The CENP-T-W-S-X complex binds, supercoils DNA and plays an important role in kinetochore assembly [ 4 ].

The APITD1/CENPS complex is composed of at least of CENP-S and CENP-X and is essential for the stable assembly of the outer kinetchore [ 5 ].

1. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol. Cell 37, 865-78
2. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol. Cell 37, 879-86
3. The fission yeast FANCM ortholog directs non-crossover recombination during meiosis. Science 336, 1585-8
4. CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. Cell 148, 487-501
5. The CENP-S complex is essential for the stable assembly of outer kinetochore structure. J. Cell Biol. 186, 173-82