InterPro domain: IPR018545

General Information

  • Identifier IPR018545
  • Description Btz domain

Abstract

This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein, also known as MLN51) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide [ 1 , 2 ].


1. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Cell 126, 713-25
2. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature 427, 753-7

Species distribution

Gene table