InterPro domain: IPR018501

The DDT has been named after the better characterised DNA-binding homeobox-containing proteins and the Different Transcription and chromatin remodellingfactors in which it is found. It is a domain of about 60 amino acids which isexclusively associated with nuclear domains like AT-Hook,PHD finger, methyl-CpG-binding domain, bromodomain and DNA-binding homeodomain.

The DDT domain is characterised by a number of conserved aromatic and chargedresidues and is predicted to consist of three alpha helices. A DNA-bindingfunction for the DDT domain has been proposed [ 1 ].

1. DDT -- a novel domain in different transcription and chromosome remodeling factors. Trends Biochem. Sci. 26, 145-6