InterPro domain: IPR018491
General Information
- Identifier IPR018491
- Description SLC12A transporter, C-terminal
- Number of genes 168
- Gene duplication stats Loading...
- Associated GO terms GO:0006811 GO:0022857 GO:0016020
Abstract
This entry represents a domain found in the C-terminal of the solute carrier family 12 (SLC12) members, which are K-Cl cotransporters. The SLC12 family members are predicted to have 12 transmembrane (TM) regions in a central hydrophobic domain, together with hydrophilic N- and C-termini that are likely cytoplasmic. Comparison of their sequences with those of other ion-tranporting membrane proteins reveals that they are part of a new superfamily of cation-chloride co-transporters, which includes the Na-Cl and Na-K-2Cl co-transporters [ 1 , 2 , 3 ].
1. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. J. Biol. Chem. 271, 16245-52
2. The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397, 251-5
3. Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter. Am. J. Physiol. 277, C1210-9