InterPro domain: IPR018477
General Information
- Identifier IPR018477
- Description Bicaudal-D protein
- Number of genes 5
- Gene duplication stats Loading...
- Associated GO terms GO:0008093 GO:0070840
Abstract
Bicaudal-D (BicD) is a family of motor adaptor proteins consist of three coiled-coiled domains. BicD plays an essential for the correct localization of maternal mRNAs in Drosophila's oocyte [ 1 ] and functions as a regulator of the Golgi to ER retrograde transport in mammalian cells [ 2 ]. BicD was suggested to be a linker bridging cargo and dynein and have roles in the regulation of cargo motility [ 3 ]. It also functions as a novel regulator of neurotrophin (NT) signaling [ 4 ].
1. Rab6 and the secretory pathway affect oocyte polarity in Drosophila. Development 134, 3419-25
2. BicaudalD actively regulates microtubule motor activity in lipid droplet transport. PLoS ONE 3, e3763
3. Bicaudal-D and its role in cargo sorting by microtubule-based motors. Biochem. Soc. Trans. 37, 1066-71
4. Neuronal Roles of the Bicaudal D Family of Motor Adaptors. Vitam. Horm. 104, 133-152