InterPro domain: IPR018033
General Information
- Identifier IPR018033
- Description D-aminoacyl-tRNA deacylase, archaea
- Number of genes 100
- Gene duplication stats Loading...
- Associated GO terms GO:0016788 GO:0051499 GO:0019478
Abstract
D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive tRNA molecules. Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino acid onto their cognate tRNA [ 1 , 2 ].
This entry represents a group of Archaeal D-aminoacyl-tRNA deacylases (also known as d-Tyr- tRNA(Tyr) deacylases) that shares homology with plant D-aminoacyl-tRNA deacylase. The expression of plant D-aminoacyl-tRNA deacylase is capable of functionally compensating in E. coli for the absence of endogeneous d-Tyr- tRNA(Tyr) deacylase [ 3 ].
1. Identification in archaea of a novel D-Tyr-tRNATyr deacylase. J. Biol. Chem. 281, 27575-85
2. GEK1, a gene product of Arabidopsis thaliana involved in ethanol tolerance, is a D-aminoacyl-tRNA deacylase. Nucleic Acids Res. 35, 930-8