InterPro domain: IPR018033

General Information

  • Identifier IPR018033
  • Description D-aminoacyl-tRNA deacylase, archaea

Abstract

D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive tRNA molecules. Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino acid onto their cognate tRNA [ 1 , 2 ].

This entry represents a group of Archaeal D-aminoacyl-tRNA deacylases (also known as d-Tyr- tRNA(Tyr) deacylases) that shares homology with plant D-aminoacyl-tRNA deacylase. The expression of plant D-aminoacyl-tRNA deacylase is capable of functionally compensating in E. coli for the absence of endogeneous d-Tyr- tRNA(Tyr) deacylase [ 3 ].


1. Identification in archaea of a novel D-Tyr-tRNATyr deacylase. J. Biol. Chem. 281, 27575-85
2. GEK1, a gene product of Arabidopsis thaliana involved in ethanol tolerance, is a D-aminoacyl-tRNA deacylase. Nucleic Acids Res. 35, 930-8

Species distribution

Gene table

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