InterPro domain: IPR017956

General Information

  • Identifier IPR017956
  • Description AT hook, DNA-binding motif
  • Number of genes 1642
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003677  

Abstract

AT hooks are DNA-binding motifs with a preference for A/T rich regions. These motifs are found in a variety of proteins, including the high mobility group (HMG) proteins [ 1 ], in DNA-binding proteins from plants [ 2 ] and in hBRG1 protein, a central ATPase of the human switching/sucrose non-fermenting (SWI/SNF) remodeling complex [ 3 ].


1. HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Biochim. Biophys. Acta 1519, 13-29
2. Novel members of a family of AT hook-containing DNA-binding proteins from rice are identified through their in vitro interaction with consensus target sites of plant and animal homeodomain proteins. Plant Mol. Biol. 31, 607-18
3. DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein. Biol. Chem. 387, 1469-78

Species distribution

Gene table