InterPro domain: IPR017920

The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet [ 1 ].

COMM (copper metabolism gene MURR1) domain proteins constitute a family initially identified as interacting partners of COMMD1 (previously known as MURR1), the prototype member of this protein family. COMMD1 is a multifunctional protein that has been shown to participate in two apparently distinct activities, regulation of the transcription factor NF-kappa-B and control of copper metabolism. The family is defined by the presence of a C-terminal motif termed COMM domain, which functions as an interface for protein-protein interactions. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms [ 2 , 2 ].

1. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 280, 22222-32
2. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem. J. 398, 63-71