InterPro domain: IPR017597

General Information

  • Identifier IPR017597
  • Description Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y

Abstract

Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH) [ 1 ]. This entry represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and carbon dioxide. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).


1. Function of several critical amino acids in human pyruvate dehydrogenase revealed by its structure. Arch. Biochem. Biophys. 429, 171-9

Species distribution

Gene table