InterPro domain: IPR017456

General Information

  • Identifier IPR017456
  • Description CTP synthase, N-terminal
  • Number of genes 436
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006221   GO:0003883  

Abstract

CTP synthase is involved in pyrimidine ribonucleotide/ribonucleoside metabolism, catalysing the synthesis of CTP from UTP by amination of the pyrimidine ring at the 4-position [ 1 ]. The enzyme exists as a dimer which consists of an N-terminal synthetase domain and C-terminal glutaminase domain that aggregates as a tetramer. This gene has been found roughly 500 bp upstream of enolase in both beta (Nitrosomonas europaea) and gamma (Escherichia coli) subdivisions of Proteobacterium [ 2 ].

This entry represents the N-terminal synthetase domain of CTP synthase.


1. Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme. J. Biol. Chem. 278, 9407-11
2. Linkage of genes encoding enolase (eno) and CTP synthase (pyrG) in the beta-subdivision proteobacterium Nitrosomonas europaea. FEMS Microbiol. Lett. 165, 153-7

Species distribution

Gene table