InterPro domain: IPR017408

Arginine N-methyltransferase 2 is a delta-N-monomethylarginine transferase which monomethylates 'Arg-67' of ribosomal protein L12 [ 1 ].

Protein arginine methyltransferases (PRMT) have been implicated in the regulation of transcription. They are recruited to promoters via their interaction with transcription factors and exert their co-activator function by methylating arginine residues in histones and other chromatin proteins [ 2 ].

1. Yeast ribosomal protein L12 is a substrate of protein-arginine methyltransferase 2. J. Biol. Chem. 277, 15345-53
2. The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation. Nucleic Acids Res. 36, 3202-13